Racial Differences in HLA Class II Associations with Hepatitis C Virus Outcomes

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Racial differences in HLA class II associations with hepatitis C virus outcomes.

A broad, vigorous CD4 T cell response, mediated by class II human leukocyte antigens (HLAs), favors hepatitis C virus (HCV) clearance. HLA-DQB1*0301 has been associated with viral clearance in an ethnically homogeneous cohort. To validate this association and to identify other class II associations in an ethnically varied cohort, molecular class II HLA typing was performed on 200 HCV clearance ...

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The importance of assessing effect modification when asserting racial differences in associations between human leukocyte antigen class II alleles and hepatitis C virus outcomes.

To the Editor—In a recent article, Thio et al. [1] sought to determine whether DQB1*0301 and other HLA class II alleles were associated with hepatitis C virus (HCV) clearance and persistence in 3 multiethnic cohorts. The results of their analyses confirmed the previously documented association of DQB1*0301 and other HLA class II alleles with viral clearance [2]. Furthermore, Thio et al. hypothe...

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Investigation of Human Leukocyte Antigen (HLA) Class I and II Alleles and Hepatitis C Virus (HCV) Genotypes in Patients Infected with HCV

Hepatitis C virus (HCV) is a major public health problem with more than 130-180 million people infected worldwide. Several studies in different populations have reported the association of human leukocyte antigen (HLA) genotypes, and HCV viral load, and genotypes. The aim of this study was to investigate a possible association between HLA class I and II alleles in HCV-infected patients and heal...

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Racial differences in hepatitis C treatment eligibility.

UNLABELLED Black Americans are disproportionally infected with hepatitis C virus (HCV) and are less likely than whites to respond to treatment with peginterferon (PEG-IFN) plus ribavirin (RBV). The impact of race on HCV treatment eligibility is unknown. We therefore performed a retrospective analysis of a phase 3B multicenter clinical trial conducted at 118 United States community and academic ...

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The occasional familial occurrence of idiopathic nephrotic syndrome (NS) points to a genetic predisposition. Reports on associations with certain HLA class II antigens support this hypothesis. In order to define the immunogenetic background of NS more precisely, HLA class II allele frequencies in 161 children with NS were studied by restriction fragment length polymorphism (RFLP) typing. The pa...

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ژورنال

عنوان ژورنال: The Journal of Infectious Diseases

سال: 2001

ISSN: 0022-1899,1537-6613

DOI: 10.1086/321005